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Immunology researchers uncover pathways that direct immune system to turn 'on' or 'off'

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(Medical Xpress)—A key discovery explaining how components of the immune system determine whether to activate or to suppress the immune system, made by Kelvin Lee, MD, Professor of Oncology and Co-Leader of the Tumor Immunology and Immunotherapy Program at Roswell Park Cancer Institute (RPCI), and colleagues led to published findings being selected as the "Paper of the Week" by the Journal of Biological Chemistry (JBC). The honor places his work among the top 2 percent—in terms of significance and overall importance—of the year's manuscripts reviewed by the journal.

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